DIABETES MELLITUS diabetes mellitus is a group of metabolic diseases characterised by hyperglycemia resulting from defects in insuline secretion,insuline action or both.diabetes is classified in 2 groups (1)type 1 diabetes caused by beta cells destruction usually leading to absolute insuline deficiency it may be due to immune mediated damage or idiopathic damage.(2) type 2 diabetes may be due to predominantly from insuline resistance with relative insuline deficiency to predominantly secretion defect with insuline resistance. Pathogenesis of diabetes mellitus (1)type 1diabetes mellitus :by the time type 1 diabetes appears,most of the beta cells in pancrease have been destroyed. A tentative overview of pathologic sequence is like (1)genetic susceptibility to the disease must be present in type 1 diabetes.the major histocompatibility complex (.MHC)is important ...
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